Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC012
Sex MALE
Dominant hand LEFT
Test date and time 2022-02-25 17:21
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment madopar a 250mg 4x1/4 madopar HBS 1 uvece

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 26 individuals with a value less than 0.61 were subsequently diagnosed with PD. That is, 61.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.61 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 24, 'TN': 21, 'TP': 18, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 17, 'TN': 12, 'TP': 25, 'FP': 18}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 39, 'TN': 29, 'TP': 3, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 11, 'TP': 22, 'FP': 19}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.032
timePerCircleCoV 0.193961
timePerCircleSlope -0.0447292
meanError 1.57506
tremorFreq 4.39453
tremorRelPower 27.2786
tremorGyroAmpMean 0.0337722
tremorGyroAmpSlope -4.24928e-05
tremorGyroAmpCoV 0.503773
tremorCoordAmpMean 0.126205
tremorCoordAmpSlope 0.00255044
tremorCoordAmpCoV 0.444259
tremorAccAmpMean 0.11981
tremorAccAmpSlope 0.000831681
tremorAccAmpCoV 0.336496
tremorPcRelVar 0.844465
tremorPcX -0.433418
tremorPcY -0.901193

Circle Segment 1

Duration 16.4 s, Accuracy Estimate 1.761 (lower is better)

Circle Segment 2

Duration 15.88 s, Accuracy Estimate 1.705 (lower is better)

Circle Segment 3

Duration 11.4 s, Accuracy Estimate 1.86 (lower is better)

Circle Segment 4

Duration 10.56 s, Accuracy Estimate 1.096 (lower is better)

Circle Segment 5

Duration 11.48 s, Accuracy Estimate 1.943 (lower is better)

Circle Segment 6

Duration 11.64 s, Accuracy Estimate 1.628 (lower is better)

Circle Segment 7

Duration 9.36 s, Accuracy Estimate 1.374 (lower is better)

Circle Segment 8

Duration 12.44 s, Accuracy Estimate 1.731 (lower is better)

Circle Segment 9

Duration 11.12 s, Accuracy Estimate 1.086 (lower is better)

Circle Segment 10

Duration 10.04 s, Accuracy Estimate 1.566 (lower is better)

Spiral

numSpirals 11
timePerSpiralMean 38.1636
timePerSpiralCoV 0.167664
timePerSpiralSlope 0.0262792
meanError 1.91846
tremorFreq 4.6875
tremorRelPower 32.5089
tremorGyroAmpMean 0.0402375
tremorGyroAmpSlope -0.000873172
tremorGyroAmpCoV 0.466825
tremorCoordAmpMean 0.148436
tremorCoordAmpSlope -0.00135387
tremorCoordAmpCoV 0.457649
tremorAccAmpMean 0.128119
tremorAccAmpSlope -0.000962998
tremorAccAmpCoV 0.450333
tremorPcRelVar 0.838108
tremorPcX -0.559198
tremorPcY -0.829034

Spiral Segment 1

Duration 35.32 s, Accuracy Estimate 1.84 (lower is better)

Spiral Segment 2

Duration 31.28 s, Accuracy Estimate 1.574 (lower is better)

Spiral Segment 3

Duration 29.88 s, Accuracy Estimate 2.116 (lower is better)

Spiral Segment 4

Duration 36.84 s, Accuracy Estimate 1.767 (lower is better)

Spiral Segment 5

Duration 36.44 s, Accuracy Estimate 1.915 (lower is better)

Spiral Segment 6

Duration 34.88 s, Accuracy Estimate 1.972 (lower is better)

Spiral Segment 7

Duration 47.48 s, Accuracy Estimate 1.661 (lower is better)

Spiral Segment 8

Duration 45.96 s, Accuracy Estimate 2.838 (lower is better)

Spiral Segment 9

Duration 47.8 s, Accuracy Estimate 1.678 (lower is better)

Spiral Segment 10

Duration 40.6 s, Accuracy Estimate 1.94 (lower is better)

Spiral Segment 11

Duration 33.32 s, Accuracy Estimate 1.804 (lower is better)

Elel

eDurationMean 0.605938
eDurationStd 0.174363
eDurationStdnorm 0.287757
eDurationMedian 0.565
eDurationQuartdelta 0.2
eDurationQuartdeltanorm 0.353982
eDurationKurt 3.62727
eDurationTrenddiff -0.15
eDurationTrendratio 0.771863
eWidthMean 6.64606
eWidthStd 2.63442
eWidthStdnorm 0.396389
eWidthMedian 5.80281
eWidthQuartdelta 4.36359
eWidthQuartdeltanorm 0.751979
eWidthKurt 3.08447
eWidthTrenddiff -4.12959
eWidthTrendratio 0.519787
eHeightMean 10.5549
eHeightStd 3.16169
eHeightStdnorm 0.299548
eHeightMedian 10.4715
eHeightQuartdelta 5.0704
eHeightQuartdeltanorm 0.48421
eHeightKurt 1.94862
eHeightTrenddiff -3.54853
eHeightTrendratio 0.722587
eAspectMean 0.651738
eAspectStd 0.23486
eAspectStdnorm 0.360359
eAspectMedian 0.635702
eAspectQuartdelta 0.322272
eAspectQuartdeltanorm 0.506953
eAspectKurt 3.28308
eAspectTrenddiff -0.199894
eAspectTrendratio 0.720939
eSlantMean 0.168605
eSlantStd 0.209521
eSlantStdnorm 1.24267
eSlantMedian 0.138477
eSlantQuartdelta 0.276571
eSlantQuartdeltanorm 1.99724
eSlantKurt 3.44115
eSlantTrenddiff -0.232873
eRtopMean 0.808856
eRtopStd 0.147747
eRtopStdnorm 0.182662
eRtopMedian 0.844465
eRtopQuartdelta 0.217212
eRtopQuartdeltanorm 0.257219
eRtopKurt 2.74096
eRtopTrenddiff -0.122182
eRbotMean 0.543689
eRbotStd 0.218956
eRbotStdnorm 0.402723
eRbotMedian 0.52439
eRbotQuartdelta 0.346889
eRbotQuartdeltanorm 0.661509
eRbotKurt 2.13497
eRbotTrenddiff 0.0953466
eRrightMean 0.8604
eRrightStd 0.13813
eRrightStdnorm 0.160541
eRrightMedian 0.923312
eRrightQuartdelta 0.162368
eRrightQuartdeltanorm 0.175854
eRrightKurt 4.63272
eRrightTrenddiff -0.0368132
eRleftMean 0.326471
eRleftStd 0.149803
eRleftStdnorm 0.458855
eRleftMedian 0.337535
eRleftQuartdelta 0.23538
eRleftQuartdeltanorm 0.697348
eRleftKurt 1.83538
eRleftTrenddiff 0.160567
lDurationMean 0.76125
lDurationStd 0.238396
lDurationStdnorm 0.313163
lDurationMedian 0.755
lDurationQuartdelta 0.31
lDurationQuartdeltanorm 0.410596
lDurationKurt 2.75259
lDurationTrenddiff -0.105
lDurationTrendratio 0.868339
lWidthMean 7.71922
lWidthStd 3.03506
lWidthStdnorm 0.393183
lWidthMedian 7.4295
lWidthQuartdelta 5.21547
lWidthQuartdeltanorm 0.701995
lWidthKurt 1.99778
lWidthTrenddiff -1.872
lWidthTrendratio 0.782313
lHeightMean 18.631
lHeightStd 3.96615
lHeightStdnorm 0.212879
lHeightMedian 18.4244
lHeightQuartdelta 4.2705
lHeightQuartdeltanorm 0.231785
lHeightKurt 4.35474
lHeightTrenddiff -2.93512
lHeightTrendratio 0.851195
lAspectMean 0.418247
lAspectStd 0.150077
lAspectStdnorm 0.358825
lAspectMedian 0.428202
lAspectQuartdelta 0.215896
lAspectQuartdeltanorm 0.504192
lAspectKurt 2.18348
lAspectTrenddiff -0.0710243
lAspectTrendratio 0.847392
lSlantMean 0.208819
lSlantStd 0.165219
lSlantStdnorm 0.791205
lSlantMedian 0.215501
lSlantQuartdelta 0.262388
lSlantQuartdeltanorm 1.21757
lSlantKurt 2.28086
lSlantTrenddiff -0.0103073
lRtopMean 0.824021
lRtopStd 0.155247
lRtopStdnorm 0.188402
lRtopMedian 0.857156
lRtopQuartdelta 0.244143
lRtopQuartdeltanorm 0.284829
lRtopKurt 2.70624
lRtopTrenddiff 0.0548213
lRbotMean 0.383834
lRbotStd 0.245219
lRbotStdnorm 0.638868
lRbotMedian 0.295675
lRbotQuartdelta 0.311028
lRbotQuartdeltanorm 1.05193
lRbotKurt 7.20259
lRbotTrenddiff -0.0552357
lRrightMean 0.901841
lRrightStd 0.0936236
lRrightStdnorm 0.103814
lRrightMedian 0.91544
lRrightQuartdelta 0.103762
lRrightQuartdeltanorm 0.113347
lRrightKurt 4.7973
lRrightTrenddiff 0.0372247
lRleftMean 0.251591
lRleftStd 0.213034
lRleftStdnorm 0.846747
lRleftMedian 0.179758
lRleftQuartdelta 0.167103
lRleftQuartdeltanorm 0.9296
lRleftKurt 4.32916
lRleftTrenddiff 0.0136426

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.945627
sumTouchScores 22.695
meanMovementTime 0.814565
numTouches 24
undershootPercentage 0
overshootPercentage 16.6667

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.644103
sumTouchScores 7.72924
meanMovementTime 1.34636
numTouches 12
undershootPercentage 16.6667
overshootPercentage 41.6667

fitts_long data not in signals file.

ZigZag

numZigzags 4
timePerZigzagMean 55.25
timePerZigzagCoV 0.160497
timePerZigzagSlope 0.00702262
meanError 2.17887
tremorFreq 6.54297
tremorRelPower 23.3379
tremorGyroAmpMean 0.0140896
tremorGyroAmpSlope 0.000740409
tremorGyroAmpCoV 0.455269
tremorCoordAmpMean 0.0326586
tremorCoordAmpSlope 0.000361651
tremorCoordAmpCoV 0.319929
tremorAccAmpMean 0.0247899
tremorAccAmpSlope 0.000255703
tremorAccAmpCoV 0.332191
tremorPcRelVar 0.676079
tremorPcX 0.418957
tremorPcY 0.908006

ZigZag Segment 1

Duration 60.88 s, Accuracy Estimate 2.021 (lower is better)

ZigZag Segment 2

Duration 42.56 s, Accuracy Estimate 2.465 (lower is better)

ZigZag Segment 3

Duration 61.8 s, Accuracy Estimate 2.09 (lower is better)

ZigZag Segment 4

Duration 55.76 s, Accuracy Estimate 2.14 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 19.744
timePerZigzagCoV 0.361487
timePerZigzagSlope -0.212925
zigzagHeightMean 66.8568
zigzagHeightCoV 0.0439992
zigzagHeightSlope 0.00144056
meanError 0.0567385
tremorFreq 5.76172
tremorRelPower 21.0036
tremorGyroAmpMean 0.0267221
tremorGyroAmpSlope 0.00589927
tremorGyroAmpCoV 0.330988
tremorCoordAmpMean 0.0727806
tremorCoordAmpSlope 0.00762689
tremorCoordAmpCoV 0.521855
tremorAccAmpMean 0.103964
tremorAccAmpSlope 0.00184309
tremorAccAmpCoV 0.129532
tremorPcRelVar 0.747934
tremorPcX -0.300275
tremorPcY 0.953853

ZigZag Offset Segment 1

Duration 30.68 s, Accuracy Estimate 0.08 (lower is better)

ZigZag Offset Segment 2

Duration 23.24 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 3

Duration 16.08 s, Accuracy Estimate 0.057 (lower is better)

ZigZag Offset Segment 4

Duration 14.88 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 5

Duration 13.84 s, Accuracy Estimate 0.068 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.61}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.4626122124478731}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9294254557879413}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}